Alopecia universalis treatment 201111/16/2023 Trial registrationĬ, NCT01673789, 21 August 2012Īlopecia areata (AA) is one of the most common T cell-mediated autoimmune skin diseases, leading to chronic and relapsing hair loss. This innovative approach produced lasting improvement in hair regrowth in subjects with moderate or severe AA. ConclusionsĬurrent clinical data demonstrated the safety and efficacy of the Stem Cell Educator therapy for the treatment of AA. Mechanistic studies revealed that co-culture with CB-SC may up-regulate the expression of coinhibitory molecules B and T lymphocyte attenuator (BTLA) and programmed death-1 receptor (PD-1) on CD8β +NKG2D + effector T cells and suppress their proliferation via herpesvirus entry mediator (HVEM) ligands and programmed death-1 ligand (PD-L1) on CB-SCs. Immunohistochemistry indicated the formation of a “ring of transforming growth factor beta 1 (TGF-β1)” around the hair follicles, leading to the restoration of immune privilege of hair follicles and the protection of newly generated hair follicles against autoimmune destruction. Flow cytometry revealed the up-regulation of Th2 cytokines and restoration of balancing Th1/Th2/Th3 cytokine production in the peripheral blood of AA subjects. ResultsĬlinical data demonstrated that patients with severe AA achieved improved hair regrowth and quality of life after receiving Stem Cell Educator therapy. ![]() The median age was 20 years (median alopecic duration, 5 years). In an open-label, phase 1/phase 2 study, patients (N = 9) with severe AA received one treatment with the Stem Cell Educator therapy. We have developed a Stem Cell Educator therapy in which a patient’s blood is circulated through a closed-loop system that separates mononuclear cells from the whole blood, allows the cells to briefly interact with adherent human cord blood-derived multipotent stem cells (CB-SC), and returns the “educated” autologous cells to the patient’s circulation. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss.
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